Because the tablet must be kept intact to prevent destruction by moisture, administration range is based on the nearest whole-tablet. The chart below is provided as a guide for administration. Daily administration may also be calculated based on 20 mg/kg of body weight and rounded to the closest tablet size or combination of sizes.
For optimal absorption, tablets should be given on an empty stomach, at least one hour before feeding, as the presence of food decreases the absorption of S-Adenosylmethionine. Studies have shown that, in many cases, tablets or capsules given as a “dry swallow” do not pass into the stomach in cats but may become lodged in the esophagus. It is recommended for pet owners to administer 3-6 cc of water immediately following any tablet administration to speed passage of the tablet into the stomach.10,11 Denosyl 90 mg tablets are ideal for cats because of their small size. If the pet is to receive more than one tablet daily, the total number of tablets may be divided between morning and evening for ease of administration. For example, a daily administration of three tablets could be divided into two tablets in the morning and one tablet in the evening.
Denosyl Canine and Feline Daily* Administration Guide
For Cats (90 mg)
| Body Weight |
Body Weight |
Number of Tablets Per Day |
| Up to 12 lbs |
Up to 5.5 kg |
1 tablet |
| Over 12 lbs |
Over 5.5 kg |
2 tablets |
For Small Dogs (90 mg)
| Body Weight |
Body Weight |
Number of Tablets Per Day |
| Up to 12 lbs |
Up to 5.5 kg |
1 tablet |
For Medium Dogs (225 mg)
| Body Weight |
Body Weight |
Number of Tablets Per Day |
| 13-34 lbs |
6-15.5 kg |
1 tablet |
For Large Dogs (425 mg)
| Body Weight |
Body Weight |
Number of Tablets Per Day |
| 35-65 lbs |
16-29.5 kg |
1 tablet |
| 66-120 lbs |
30-54.5 kg |
2 tablets |
| Over 120 lbs |
Over 54.5 kg |
3 tablets |
*The number of tablets can be gradually reduced or increased at any time depending on the pet's needs.
Many pets are maintained long-term on every-other-day or every-third-day administration.
Storage
Store in a cool dry place. Keep tablets in original blister pack until used. Tablets are sensitive to moisture and extreme heat.
