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Atopica targets the cause of the problem to help reduce the incessant scratching, rubbing and licking.
ATOPICA is indicated for the control of atopic dermatitis in dogs weighing at least 4 pounds.
Important Safety Information: Do not use Atopica in dogs with a history of neoplasia, with a hypersensitivity to cyclosporine, or in reproducing dogs.
For more information see product label.
Cyclosporine does not mix well with other medicine
According to a 2014 study in the Journal of Veterinary Medicine, cyclosporine is linked to a large number of drug interactions in dogs, that can also affect blood cyclosporine concentrations.
Although in the U.S it is mainly used to treat dogs with atopic dermatitis, there are numerous uses for this drug. “Cyclosporine is an immunomodulatory drug used to treat an increasing spectrum of diseases in dogs.
Cyclosporine is a calcineurin inhibitor, ultimately exerting its inhibitory effects on T-lymphocytes by decreasing production of cytokines, such as interleukin. Ultra-micronized cyclosporine is available as an approved animal product, and human proprietary and generic preparations are also available. Bioavailability of the different formulations in dogs is likely to vary among the preparations.” [4]
The study also indicates that drug therapy monitoring (DTM) of Atopica [5] is necessary, to keep consistent plasma cyclosporine concentrations regardless of bioavailability and drug interactions, and to ensure successful treatment.
Cyclosporine has a high binding affinity for red blood cells and plasma lipoproteins. About 50% of this drug is found in the red blood cells after administration, making the need for whole blood necessary for therapeutic drug monitoring.
After circulation, cyclosporine distributes everywhere from kidneys, liver, skin, and the fat of dogs. Peak concentrations are 2 hours after administration. There are some drug interactions with cyclosporine that will either lead to an increase or decrease of cyclosporine concentrations.
There are numerous drugs that interact with cyclosporine.
That said, it is necessary to discuss with your veterinarian any medications, prescriptions, over-the-counter, or herbal preparations that you are giving to your dog. You will also need to educate yourself on how cyclosporine works, and any possible side effects that this drug may have on your dog.
Cyclosporine is an immunosuppressant and cannot be used on dogs weighing less than 4 pounds. Dosage has to be according to veterinary instructions. The complete list of all drugs that may interact with cyclosporine is available at your veterinarians office.
The list below highlights a few of the drugs that interact with Atopica. It is necessary to discuss all medications that your dog is on with your vet before the administration of a cyclosporine drug like Atopica.
Before prescribing Atopica, your veterinarian will most likely begin by discussing treatment options. They will recommend and advise you about the specific disorder, and the recommended drugs that will be needed to treat the disease.
You and your vet will need to thoroughly discuss any medications, prescriptions, over-the-counter, or herbal products that you are giving your dog. You will also need to inform yourself about how Atopica works, and any possible side effects that this drug may have on your dog.
Most importantly, you will need to prepare yourself in advance should there be any side effects that would need immediate emergency veterinary care. Even if Atopica seems easy enough to use, or you’ve given this to your dog in the past, it’s still important to follow all instructions carefully. Correct dosages must be administered at all times.
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